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[DOI] [Google Scholar] 47.Ding S., Barr J.A., Lyu Z., Zhang F., Wang M., Tieu P., Li X., Engelhard M.H., Feng Z., Beckman S.P., et al

The sirtuins are NAD + -dependent deacetylases that are distributed in the nucleus (e.g., SIRT1, SIRT6, and SIRT7), the cytoplasm (e.g., SIRT2) and mitochondria (e.g., SIRT3-5), respectively

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71 ROS can also activate downstream effectors like PKC 72 and JNK, 73 which are independently associated with DPN pathology

occasional reports of mild headache, transient jitteriness, or injection-site reactions